WHO Africa Region Bacterial Antimicrobial Resistance Burden Estimates 2019

Researchers at IHME and the University of Oxford estimated deaths, disability-adjusted life years (DALYs), years lived with disability (YLDs), and years of life lost (YLLs) associated with and attributable to bacterial antimicrobial resistance (AMR) in 88 pathogen-drug combinations for the WHO Region of Africa and for 35 countries in 2019. Data gathered to inform these estimates included multiple cause of death data, hospital discharges, minimally invasive tissue sampling, systematic literature reviews, and microbiology lab results from hospitals and national and multi-national surveillance systems, totaling 343 million individual records or isolates and 11,361 study-location-years collected. These data informed 8 modelling components which were combined with results from GBD 2019 to estimate AMR burden. Estimates were produced for two counterfactual scenarios: no infection and drug-susceptible infection.